Research Interest
Overview of the work:
Protein-protein interactions (PPI), typify physical, signaling and regulatory networks that orchestrate cellular responses. PPI are sensitive to protein levels, mutations, post translational modifications (PTM), and subcellular boundaries to name a few. Cancer cells exploit these to rewire networks to maintain mosaic correlations that allow them to survive. The lab tries to understand PPIs at different hierarchical levels with a long-term goal of exposing the Achilles heel in cancer.
Current activities include:
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Mapping the molecular details of individual PPIs and characterizing the hot spot sides of interaction
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Exploiting them for the design and evolution of inhibitors
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Structure guided construction of first neighborhood subnetworks.
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Inferring function and regulation through domain motif interaction
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Expanding the networks by expression analysis and APMS derived PPI
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Deriving context specific pathways that can be described by edge level metrics.